Selected Publications
Selected Publications on micro and non-coding RNAs
1: Silambarasan M, Tan JR, Karolina DS, Armugam A, Kaur C, Jeyaseelan K. microRNAs in hyperglycemia induced endothelial cell dysfunction. Int J Mol Sci, 2016 17, 518
2: Kaur P, Tan JR, Karolina DS, Sepramaniam S, Armugam A, Peter Wong TH, Jeyaseelan K. Supporting data for characterization of non-coding RNAs associated with the Neuronal growth regulator 1 (NEGR1) adhesion protein. Data Brief. 2016 Feb 27;7:381-5.
3: Kaur P, Tan JR, Karolina DS, Sepramaniam S, Armugam A, Wong PT, Jeyaseelan K. A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of neuronal growth regulator 1 (NEGR1) adhesion protein. Biochim Biophys Acta. 2016 Apr;1863(4):533-43.
4: Tambyah PA, Ching CS, Sepramaniam S, Ali JM, Armugam A, Jeyaseelan K. microRNA expression in blood of dengue patients. Ann Clin Biochem. 2016 July; 53 (Pt 4):466-76.
5: Liu FJ, Kaur P, Karolina DS, Sepramaniam S, Armugam A, Wong PT, Jeyaseelan K. MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. PLoS One. 2015 Jun 1;10(6):e0128432.
6: Wong LL, Wee AS, Lim JY, Ng JY, Chong JP, Liew OW, Lilyanna S, Martinez EC, Ackers-Johnson MA, Vardy LA, Armugam A, Jeyaseelan K, Ng TP, Lam CS, Foo RS, Richards AM, Chen YT. Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100. J Mol Cell Cardiol. 2015 May;82:13-21.
7: Wong LL, Armugam A, Sepramaniam S, Karolina DS, Lim KY, Lim JY, Chong JP, Ng JY, Chen YT, Chan MM, Chen Z, Yeo PS, Ng TP, Ling LH, Sim D, Leong KT, Ong HY, Jaufeerally F, Wong R, Chai P, Low AF, Lam CS, Jeyaseelan K, Richards AM. Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction. Eur J Heart Fail. 2015 Apr;17(4):393-404.
8: Karolina DS, Armugam A, Sepramaniam S, Pek SLT, Wong MTK, Lim SC, Sum CF, Tavintharan S and Jeyaseelan K. miR-22 and miR-23a Control Glycerol-Dependent Gluconeogenesis by Regulating Aquaporin 9 Expression. Metabolomics 2014 S2:002. doi: 10.4172/2153-0769.S2-002
9: Sepramaniam S, Tan JR, Tan KS, Desilva DA, Tavintharan S, Woon FP, Wang CW, Yong FL, Karolina DS, Kaur P, Liu FJ, Lim KY, Armugam A, Jeyaseelan K. Circulating MicroRNAs as Biomarkers of Acute Stroke. Int J Mol Sci. 2014 Jan 20;15(1):1418-32.
10:Tambyah PA, Sepramaniam S, Mohamed Ali J, Chai SC, Swaminathan P, Armugam A, Jeyaseelan K. microRNAs in Circulation Are Altered in Response to Influenza A Virus Infection in Humans. PLoS One. 2013 Oct 7;8(10):e76811.
11: Setyowati Karolina D, Sepramaniam S, Tan HZ, Armugam A, Jeyaseelan K. miR-25 and miR-92a regulate insulin I biosynthesis in rats. RNA Biol. 2013 Aug 1;10(8):1365-78.
12: Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, Armugam A, Jeyaseelan K, Choolani M, Biswas A, Bongso A. Human umbilical cord Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. J Cell Biochem. 2014 Feb: 115(2):290-302
13: Liu F, Lim KY, Kaur P, Sepramaniam S, Armugam A, Wong PTH and Jeyaseelan K. microRNAs involved in regulating spontaneous recovery in embolic stroke model PLoS One, 2013 Jun18; 8(6): e66393.
14: Sepramaniam S, Jeyaseelan K. Era of the tiny titans: microRNAs. Bioessays.2013 June;35(6):502
15: Tan JR, Tan KS, Koo YX, Yong FL, Wang CW, Armugam A, Jeyaseelan K. Blood microRNAs in Low or No Risk Ischemic Stroke Patients. Int J Mol Sci. 2013 Jan 22;14(1):2072-84.
16: Lin J, Teo S, Lam DH, Jeyaseelan K, Wang S. MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 2012 Oct 4;3:e398.
17: Karolina DS, Tavintharan S, Armugam A, Sepramaniam S, Pek SL, Wong MT, Lim SC, Sum CF, Jeyaseelan K. Circulating miRNA profiles in patients with metabolic syndrome. J Clin Endocrinol Metab. 2012 Dec;97(12):E2271-6.
18: Kaur P, Armugam A, Jeyaseelan K. MicroRNAs in Neurotoxicity. J Toxicol.2012;2012:870150. doi: 10.1155/2012/870150. Epub 2012 Mar 6. PubMed PMID:22523492.
19: Armugam A, Koh DC, Ching CS, Chandrasekaran K, Kaur P, Jeyaseelan K. Pro-domain in precursor nerve growth factor mediates cell death. Neurochem Int. 2012 Jun;60(8):852-63.
20: Sepramaniam S, Ying LK, Armugam A, Wintour EM, Jeyaseelan K. MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter. J Biol Chem. 2012 Apr 6;287(15):12006-15.
21: Chandrasekaran K, Karolina DS, Sepramaniam S, Armugam A, Wintour EM, Bertram JF, Jeyaseelan K. Role of microRNAs in kidney homeostasis and disease. Kidney Int. 2012 Apr81(7):617-27.
22: Karolina DS, Armugam A, Tavintharan S, Wong MT, Lim SC, Sum CF, Jeyaseelan K. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus. PLoS One. 2011;6(8):e22839.
23: Tan JR, Koo YX, Kaur P, Liu F, Armugam A, Wong PT, Jeyaseelan K. microRNAs in stroke pathogenesis. Curr Mol Med. 2011 Mar;11(2):76-92.
24: Sepramaniam S, Armugam A, Lim KY, Karolina DS, Swaminathan P, Tan JR, Jeyaseelan K. MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia. J Biol Chem. 2010 Sep 17;285(38):29223-30.
25: Karolina DS, Wintour EM, Bertram J, Jeyaseelan K. Riboregulators in kidney development and function. Biochimie. 2010 Mar;92(3):217-25.
26: Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW, Jeyaseelan K. Expression profile of MicroRNAs in young stroke patients. PLoS One. 2009 Nov 2;4(11):e7689.
27: Armugam A, Cher CD, Lim K, Koh DC, Howells DW, Jeyaseelan K. A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis. BMC Neurosci. 2009 Sep 23;10:120.
28: Tavintharan S, Chi LS, Fang SC, Arunmozhiarasi A, Jeyaseelan K. Riboregulators and metabolic disorders: getting closer towards understanding the pathogenesis of diabetes mellitus? Curr Mol Med. 2009 Apr;9(3):281-6. Review.
29: Chua JH, Armugam A, Jeyaseelan K. MicroRNAs: biogenesis, function and applications. Curr Opin Mol Ther. 2009 Apr;11(2):189-99. Review.
30: Jeyaseelan K, Lim KY, Armugam A. Neuroprotectants in stroke therapy. Expert Opin Pharmacother. 2008 Apr;9(6):887-900. doi: 10.1517/14656566.9.6.887. Review.
31: Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008 Mar;39(3):959-66.
32: Jeyaseelan K, Herath WB, Armugam A. MicroRNAs as therapeutic targets in human diseases. Expert Opin Ther Targets. 2007 Aug;11(8):1119-29. Review.
Selected Publications on Aquaporins
1:Xie WY, Low JWJ, Armugam A, Jeyaseelan K and Tong YW. Regulation of Aquaporin Z osmotic permeability in ABA tri-block copolymer. AIMS Biophys. 2015: 381-397.
2:Wang HL, Chung TS, Tong YW, Jeyaseelan K, Armugam A, Phuoc HHD, Fu FJ, Seah H, Yang J, Hong MH Mechanically robust and highly permeable AquaporinZ biomimetic membranes. Journal of Membrane Science. 2013;434:130–136
3:Xie WY, He F, Wang BF, Chung TS, Jeyaseelan K, Armugam A, Tong YW. An aquaporin-based vesicle-embedded polymeric membrane for low energy water filtration J. Mater. Chem. A, 2013;1:7592-7600
4:Sun, GF., Chung, TS., Jeyaseelan, K., Armugam, A. A layer-by-layer self-assembly approach to developing an aquaporin-embedded mixed matrix membrane. RSC Advances, 2013; 3(2):473-481
5:Sun G, Chung TS, Jeyaseelan K, Armugam A. Stabilization and immobilization of aquaporin reconstituted lipid vesicles for water purification. Colloids Surf B Biointerfaces. 2013;102:466-71.
6:Duong, H H P, Chung N T S, Jeyaseelan, K, Armugam, A, Yang, J and Hong, MH. Planar biomimetic aquaporin-incorporated triblock copolymer membranes on porous alumina supports for nanofiltration. Journal of Membrane Science, 2012, 409– 410: 34-43.
7:Zhong PS, Chung TS, Jeyaseelan K, Armugam A. Aquaporin-embedded biomimetic membranes for nanofiltration. Journal of Membrane Science, 2012, 407– 408: 27-33.
8:Wang H, Chung TS, Tong YW, Jeyaseelan K, Armugam A, Chen Z, Hong M, Meier W. Highly permeable and selective pore-spanning biomimetic membrane embedded with aquaporin Z. Small. 2012 Apr 23;8(8):1185-90, 1125.
9:Sun G, Zhou H, Li Y, Jeyaseelan K, Armugam A, Chung TS. A novel method of AquaporinZ incorporation via binary-lipid Langmuir monolayers. Colloids Surf B Biointerfaces. 2012 Jan1;89:283-8.
10:Wang, H, Chung, N T S, Tong, Y W, Chen, Z, Hong, MH, Jeyaseelan, K and Armugam, A. Preparation and characterization of pore-suspending biomimetic membranes embedded with Aquaporin Z. Soft Matter, 2011, 7: 7274-7280.
11:Sepramaniam S, Ying LK, Armugam A, Wintour EM, Jeyaseelan K. MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter. J Biol Chem. 2012 Apr 6;287(15):12006-15.
12:Sepramaniam S, Armugam A, Lim KY, Karolina DS, Swaminathan P, Tan JR, Jeyaseelan K. MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia. J Biol Chem. 2010 Sep 17;285(38):29223-30.
13:Jessica Chen M, Sepramaniam S, Armugam A, Shyan Choy M, Manikandan J, Melendez AJ, Jeyaseelan K, Sang Cheung N. Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system? Curr Neuropharmacol. 2008 Jun;6(2):102-16.
14:Jeyaseelan K, Sepramaniam S, Armugam A, Wintour EM. Aquaporins: a promising target for drug development. Expert Opin Ther Targets. 2006 Dec;10(6):889-909.
15:Cher CD, Armugam A, Lachumanan R, Coghlan MW, Jeyaseelan K. Pulmonaryinflammation and edema induced by phospholipase A2: global gene analysis and effects on aquaporins and Na+/K+-ATPase. J Biol Chem. 2003 Aug 15;278(33):31352-60.
16:Liu H, Hooper SB, Armugam A, Dawson N, Ferraro T, Jeyaseelan K, Thiel A,Koukoulas I, Wintour EM. Aquaporin gene expression and regulation in the ovine fetal lung. J Physiol. 2003 Sep 1;551(Pt 2):503-14.
17:Johnston H, Koukoulas I, Jeyaseelan K, Armugam A, Earnest L, Baird R, Dawson N, Ferraro T, Wintour EM. Ontogeny of aquaporins 1 and 3 in ovine placenta and fetal membranes. Placenta. 2000 Jan;21(1):88-99. PubMed PMID: 10692256
18:Butkus A, Earnest L, Jeyaseelan K, Moritz K, Johnston H, Tenis N, Wintour EM. Ovine aquaporin-2: cDNA cloning, ontogeny and control of renal gene expression. Pediatr Nephrol.1999Jun3(5):379-90.
19:Wintour EM, Earnest L, Alcorn D, Butkus A, Shandley L, Jeyaseelan K. Ovine AQP1: cDNA cloning, ontogeny, and control of renal gene expression. Pediatr Nephrol. 1998 Sep;12(7):545-53.
Patents
1.Method of making a membrane and a membrane for water filtration. Patent application no. PCT/SG2013/000227
2. Pore-spanning biomimetic membranes embedded with aquaporin, Singapore patent application No. SG201103837-9 (May 26, 2011). PCT Application No.: PCT/SG2012/000186.
3. A novel therapeutics and prophylactic agents and methods of using the same. US patent granted in 2009 (No. 0027764-A1)
4. Cholesterol biosynthesis pathway modulators and uses thereof. Word wide patent (No. 108928-A1); Granted in Europe, Germany & Switzerland in 2010
5. Phospholipase and uses thereof US Patent application filed in June 2006 (PCT/SG2006/000162) Granted in 2011
6. MicroRNA-320 for a combinatorial treatment of acute ischemic stroke. US Patent application filed in May 2012 (US 61/650 009)
In addition to peer reviewed Publications and Patents (see Web of Science and the list of Publications), my laboratory has deposited 149 gene sequences and 280 protein sequences, 23 GEO submissions and 3 OMIM records in public databases such as NCBI and Protein databases (USA and worldwide).
